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JA carried out the cytotrophoblast transmission electron microscopy (TEM) analyses, western blot (WB) and half of immunofluorescence (IF) experiments. MMK performed half of IF experiments and participated in WBs together with AT and AF and analyzed clinical data. MMK, AF and JS carried out STB and endothelium TEM analyses. LE performed the studies on mitochondrial isolates and prepared samples for lipidomic analyses. TG prepared figure 1. MMK and IC wrote the manuscript, and all authors contributed toward data interpretation and critically revising the paper and accepted the final version. MMK and IC are the guarantors of this work and, as such, had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

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